Antidepressants: Effective in Improving Mood and Easing Pain?


A controversial new study suggests the widely prescribed depression within 10 days to two weeks. “About 65% see improvement on the first antidepressant, and 85% of patients succeed on one to three antidepressant trials.”

Why wouldn’t an antidepressant work?

According to Fieve, sometimes the doctor chooses the wrong antidepressant, or the right antidepressant in the wrong dosage, or does not administer the antidepressant for at least six weeks at the highest dose tolerable to achieve full therapeutic results.

In addition, if the depressed patient has problems with alcohol or drug abuse and takes an antidepressant, the medication isn’t getting at the real problem. There are also patients who are heavily medicated on tranquilizers who wonder why an antidepressant doesn’t work to ease their causes of depression are many. For some, depression occurs after loss of a loved one, a change in one’s life such as getting divorced, or after being diagnosed with a serious medical disease. For others, depression just happens, possibly because of their family history. Medications can cause depression, and nearly 30% of people with substance abuse problems also have major depression.

How do most doctors treat depression?

Standard treatment of depression includes antidepressants and/or psychotherapy, as well as a multifaceted program of diet and lifestyle changes and alternative therapies. Experts believe that different treatment approaches work for different people — and it’s not easy to predict what might work.

What if my antidepressant doesn’t seem to work?

Talk to your doctor. You may need to try a different type of antidepressant until you find the right fit and may need additional treatment, such as talk therapy. Just like with any chronic medical condition, it takes patience and perseverance to get the best outcome with depression.